Grant opportunity

Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) is to support implementation research on strategies to improve the uptake, implementation, sustainment, scale and/or spread of evidence-based prevention, treatment, and care interventions in communities in the U.S. significantly impacted by HIV. Projects should be large in scale with high potential for research and public health impact. Specifically, large single site studies, multi-site studies, and comparative studies are encouraged as scientifically appropriate.

GrantHealth and Biomedical SciencesUnited StatesNational Institutes of HealthGrants.gov
Funder
National Institutes of Health
Applications close 2029-06-20
Applications close 2029-06-20: Jun 20, 2029
Award
See official notice
Applicant
Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; County governments; City or township governments; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized); Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Independent school districts
Discipline
Health and Biomedical Sciences
Region
United States
Posted
Oct 27, 2026

Call summary

Overview

Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional) is an official Grants.gov notice published between 30 September and 27 October 2026. Opportunity number: RFA-AI-27-018

Who can apply

Eligible applicant types listed by the agency: Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; County governments; City or township governments; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized); Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Independent school districts. Applicants must also satisfy every programme-specific condition in the official notice.

What it supports

  • The purpose of this notice of funding opportunity (NOFO) is to support implementation research on strategies to improve the uptake, implementation, sustainment, scale and/or spread of evidence-based prevention, treatment, and care interventions in communities in the U.S. significantly impacted by HIV. Projects should be large in scale with high potential for research and public health impact. Specifically, large single site studies, multi-site studies, and comparative studies are encouraged as scientifically appropriate.
  • Opportunity number: RFA-AI-27-018

Funding and duration

  • Award ceiling: See official notice
  • Expected number of awards: 10

Applications close 2029-06-20

Applications close 2029-06-20: Jun 20, 2029

How to apply

Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.

Call details

Source-based overview

The purpose of this notice of funding opportunity (NOFO) is to support implementation research on strategies to improve the uptake, implementation, sustainment, scale and/or spread of evidence-based prevention, treatment, and care interventions in communities in the U.S. significantly impacted by HIV. Projects should be large in scale with high potential for research and public health impact. Specifically, large single site studies, multi-site studies, and comparative studies are encouraged as scientifically appropriate. The official record contains the controlling eligibility, budget, attachment and submission requirements for opportunity RFA-AI-27-018.

Eligibility

Eligible applicant types listed by the agency: Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; County governments; City or township governments; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized); Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Independent school districts. Applicants must also satisfy every programme-specific condition in the official notice.

Funding and benefits

Award ceiling: See official notice

Expected number of awards: 10

Themes and supported activities

The purpose of this notice of funding opportunity (NOFO) is to support implementation research on strategies to improve the uptake, implementation, sustainment, scale and/or spread of evidence-based prevention, treatment, and care interventions in communities in the U.S. significantly impacted by HIV. Projects should be large in scale with high potential for research and public health impact. Specifically, large single site studies, multi-site studies, and comparative studies are encouraged as scientifically appropriate.

Opportunity number: RFA-AI-27-018

Deadline and timeline

Applications close 2029-06-20: Applications close 2029-06-20: Jun 20, 2029.

Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.

How to apply

Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.

Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.