Grant opportunity
Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials (R34 Clinical Trial Optional)
The purpose of this notice of funding opportunity (NOFO) is to support pilot and feasibility studies to inform the design and conduct of efficacy, effectiveness, and/or services research trials. Topics may include: 1) developing interventions to prevent substance use, misuse, or progression to substance use disorder; 2) prevention, treatment, or recovery services research, including research addressing comorbid pain and medical and mental health disorders; and 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations.
- Funder
- National Institutes of Health
- Applications close 2029-07-16
- Applications close 2029-07-16: Jul 16, 2029
- Award
- USD 450,000
- Applicant
- Independent school districts; Special district governments; For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; Native American tribal governments (Federally recognized); County governments; Public and State controlled institutions of higher education; Private institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; City or township governments; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Discipline
- Health and Biomedical Sciences
- Region
- United States
- Posted
- Oct 27, 2026
Call summary
Overview
Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials (R34 Clinical Trial Optional) is an official Grants.gov notice published between 30 September and 27 October 2026. Opportunity number: PAR-28-093
Who can apply
Eligible applicant types listed by the agency: Independent school districts; Special district governments; For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; Native American tribal governments (Federally recognized); County governments; Public and State controlled institutions of higher education; Private institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; City or township governments; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education. Applicants must also satisfy every programme-specific condition in the official notice.
What it supports
- The purpose of this notice of funding opportunity (NOFO) is to support pilot and feasibility studies to inform the design and conduct of efficacy, effectiveness, and/or services research trials. Topics may include: 1) developing interventions to prevent substance use, misuse, or progression to substance use disorder; 2) prevention, treatment, or recovery services research, including research addressing comorbid pain and medical and mental health disorders; and 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations.
- Opportunity number: PAR-28-093
Funding and duration
- Award ceiling: USD 450,000
Applications close 2029-07-16
Applications close 2029-07-16: Jul 16, 2029
How to apply
Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.
Call details
Source-based overview
The purpose of this notice of funding opportunity (NOFO) is to support pilot and feasibility studies to inform the design and conduct of efficacy, effectiveness, and/or services research trials. Topics may include: 1) developing interventions to prevent substance use, misuse, or progression to substance use disorder; 2) prevention, treatment, or recovery services research, including research addressing comorbid pain and medical and mental health disorders; and 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations. The official record contains the controlling eligibility, budget, attachment and submission requirements for opportunity PAR-28-093.
Eligibility
Eligible applicant types listed by the agency: Independent school districts; Special district governments; For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; Native American tribal governments (Federally recognized); County governments; Public and State controlled institutions of higher education; Private institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; City or township governments; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal organizations (other than Federally recognized tribal governments); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education. Applicants must also satisfy every programme-specific condition in the official notice.
Funding and benefits
Award ceiling: USD 450,000
Themes and supported activities
The purpose of this notice of funding opportunity (NOFO) is to support pilot and feasibility studies to inform the design and conduct of efficacy, effectiveness, and/or services research trials. Topics may include: 1) developing interventions to prevent substance use, misuse, or progression to substance use disorder; 2) prevention, treatment, or recovery services research, including research addressing comorbid pain and medical and mental health disorders; and 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations.
Opportunity number: PAR-28-093
Deadline and timeline
Applications close 2029-07-16: Applications close 2029-07-16: Jul 16, 2029.
Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.
How to apply
Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.
Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.