Substance Use PCORI Funding Announcement -- Cycle 3 2026

This is a pre-announcement. Use it for early planning and return to the official page when the full application package or portal opens.

PCORI intends to issue a Cycle 3 2026 PFA focused on high-quality patient-centered comparative clinical effectiveness research for substance use, misuse, and substance use disorders.

Patient-Centered Outcomes Research Institute (PCORI) lists this opportunity for Research Team, Health & Biomedical Sciences, United States. Applicants should use the official call page to confirm final requirements before submitting.

Research teams should develop patient-centered CER studies with meaningful contributions from people with lived experience and other stakeholders.

Studies must include at least one primary outcome focused on substance use.

Evidence-based prevention and treatment strategies for substance use disorders.

Overdose prevention interventions, nicotine and tobacco reduction strategies, and approaches addressing the intersection of poor sleep with substance misuse or substance use disorder.

PCORI lists up to USD 60 million available, with total direct costs up to USD 12 million per project and maximum project periods up to five years.

LOI deadline: LOI deadline: Sep 8, 2026.

Confirm the exact deadline time, time zone, and submission route on the official call page.

Plan internal approvals, partner confirmations, budgets, letters, and portal submission before the final deadline.

Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.

Before submitting, check required documents, eligible costs, attachments, page limits, institutional approvals, and whether the opportunity uses an expression of interest, full proposal, registration, or nomination stage.