Grant opportunity
Substance Use PCORI Funding Announcement -- Cycle 3 2026
PCORI pre-announcement for patient-centered comparative clinical effectiveness research on substance use, misuse, and substance use disorders.
- Funder
- Patient-Centered Outcomes Research Institute (PCORI)
- LOI deadline
- LOI deadline: Sep 8, 2026
- Award
- Up to USD 12 million direct costs; USD 60 million total fund
- Applicant
- Research Team
- Discipline
- Health & Biomedical Sciences
- Region
- United States
- Posted
- May 16, 2026
Call summary
Overview
PCORI intends to issue a Cycle 3 2026 PFA focused on high-quality patient-centered comparative clinical effectiveness research for substance use, misuse, and substance use disorders.
Who can apply
- Research teams should develop patient-centered CER studies with meaningful contributions from people with lived experience and other stakeholders.
- Studies must include at least one primary outcome focused on substance use.
What it supports
- Evidence-based prevention and treatment strategies for substance use disorders.
- Overdose prevention interventions, nicotine and tobacco reduction strategies, and approaches addressing the intersection of poor sleep with substance misuse or substance use disorder.
Funding and duration
PCORI lists up to USD 60 million available, with total direct costs up to USD 12 million per project and maximum project periods up to five years.
LOI deadline
LOI deadline: Sep 8, 2026
How to apply
Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.
Call details
About the opportunity
This is a pre-announcement. Use it for early planning and return to the official page when the full application package or portal opens.
PCORI intends to issue a Cycle 3 2026 PFA focused on high-quality patient-centered comparative clinical effectiveness research for substance use, misuse, and substance use disorders.
Patient-Centered Outcomes Research Institute (PCORI) lists this opportunity for Research Team, Health & Biomedical Sciences, United States.
This listing is written for researchers, students, universities, NGOs, research teams, policy professionals and academic institutions searching for Health & Biomedical Sciences grants, fellowships, scholarships, conferences, workshops and funding opportunities in United States contexts.
Eligibility
Research teams should develop patient-centered CER studies with meaningful contributions from people with lived experience and other stakeholders.
Studies must include at least one primary outcome focused on substance use.
Funding and benefits
PCORI lists up to USD 60 million available, with total direct costs up to USD 12 million per project and maximum project periods up to five years.
Themes and supported activities
Evidence-based prevention and treatment strategies for substance use disorders.
Overdose prevention interventions, nicotine and tobacco reduction strategies, and approaches addressing the intersection of poor sleep with substance misuse or substance use disorder.
Deadline and timeline
LOI deadline: LOI deadline: Sep 8, 2026.
Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.
How to apply
Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.
Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.