Open Competition: Implementation of Findings From PCORI's Research Investments -- Cycle 3 2026

This is a pre-announcement. Use it for early planning and return to the official page when the full application package or portal opens.

PCORI intends to release an open competition implementation PFA for projects that promote uptake of selected peer-reviewed findings from PCORI-funded patient-centered comparative clinical effectiveness research.

Patient-Centered Outcomes Research Institute (PCORI) lists this opportunity for Research Team, Health & Biomedical Sciences, United States. Applicants should use the official call page to confirm final requirements before submitting.

Implementation experts, principal investigators, patients, and stakeholder partners may propose projects; applicants do not have to have been associated with the original PCORI-funded studies.

Applicants must focus on the eligible evidence areas identified for the Cycle 3 2026 PFA.

Implementation projects that adapt, scale up, or scale out selected PCORI evidence in health systems and other real-world contexts.

Projects should include a rigorous evaluation plan and demonstrate commitment and buy-in from implementation sites and relevant stakeholder organisations.

Applicants may propose budgets up to USD 1.8 million in total direct costs, with project periods up to four years.

LOI deadline: LOI deadline: Sep 8, 2026.

Confirm the exact deadline time, time zone, and submission route on the official call page.

Plan internal approvals, partner confirmations, budgets, letters, and portal submission before the final deadline.

Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.

Before submitting, check required documents, eligible costs, attachments, page limits, institutional approvals, and whether the opportunity uses an expression of interest, full proposal, registration, or nomination stage.