Grant opportunity
Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research -- Cycle 3 2026
PCORI pre-announcement for methods research that improves how patient-centered comparative clinical effectiveness research is designed, conducted, and interpreted.
- Funder
- Patient-Centered Outcomes Research Institute (PCORI)
- LOI deadline
- LOI deadline: Sep 8, 2026
- Award
- See PCORI announcement for final budget limits
- Applicant
- Research Team
- Discipline
- Health & Biomedical Sciences
- Region
- United States
- Posted
- May 16, 2026
Call summary
Overview
PCORI intends to release a Cycle 3 2026 methods PFA to support improvements in patient-centered comparative clinical effectiveness research methods.
Who can apply
- Methods research teams should check the final PFA when it opens for topic priorities, responsiveness rules, and submission requirements.
- Projects should be relevant to the conduct, analysis, interpretation, or use of patient-centered comparative clinical effectiveness research.
What it supports
- Research methods for improving patient-centered comparative clinical effectiveness research.
- Applicants should use the official PFA, once released, to confirm specific priority areas and allowable approaches.
Funding and duration
Budget limits and project-period rules should be confirmed on the official PCORI PFA page when the full announcement is released.
LOI deadline
LOI deadline: Sep 8, 2026
How to apply
Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.
Call details
About the opportunity
This is a pre-announcement. Use it for early planning and return to the official page when the full application package or portal opens.
PCORI intends to release a Cycle 3 2026 methods PFA to support improvements in patient-centered comparative clinical effectiveness research methods.
Patient-Centered Outcomes Research Institute (PCORI) lists this opportunity for Research Team, Health & Biomedical Sciences, United States.
This listing is written for researchers, students, universities, NGOs, research teams, policy professionals and academic institutions searching for Health & Biomedical Sciences grants, fellowships, scholarships, conferences, workshops and funding opportunities in United States contexts.
Eligibility
Methods research teams should check the final PFA when it opens for topic priorities, responsiveness rules, and submission requirements.
Projects should be relevant to the conduct, analysis, interpretation, or use of patient-centered comparative clinical effectiveness research.
Funding and benefits
Budget limits and project-period rules should be confirmed on the official PCORI PFA page when the full announcement is released.
Themes and supported activities
Research methods for improving patient-centered comparative clinical effectiveness research.
Applicants should use the official PFA, once released, to confirm specific priority areas and allowable approaches.
Deadline and timeline
LOI deadline: LOI deadline: Sep 8, 2026.
Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.
How to apply
Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.
Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.