Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research -- Cycle 3 2026

This is a pre-announcement. Use it for early planning and return to the official page when the full application package or portal opens.

PCORI intends to release a Cycle 3 2026 methods PFA to support improvements in patient-centered comparative clinical effectiveness research methods.

Patient-Centered Outcomes Research Institute (PCORI) lists this opportunity for Research Team, Health & Biomedical Sciences, United States. Applicants should use the official call page to confirm final requirements before submitting.

Methods research teams should check the final PFA when it opens for topic priorities, responsiveness rules, and submission requirements.

Projects should be relevant to the conduct, analysis, interpretation, or use of patient-centered comparative clinical effectiveness research.

Research methods for improving patient-centered comparative clinical effectiveness research.

Applicants should use the official PFA, once released, to confirm specific priority areas and allowable approaches.

Budget limits and project-period rules should be confirmed on the official PCORI PFA page when the full announcement is released.

LOI deadline: LOI deadline: Sep 8, 2026.

Confirm the exact deadline time, time zone, and submission route on the official call page.

Plan internal approvals, partner confirmations, budgets, letters, and portal submission before the final deadline.

Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.

Before submitting, check required documents, eligible costs, attachments, page limits, institutional approvals, and whether the opportunity uses an expression of interest, full proposal, registration, or nomination stage.