Grant opportunity
Broad Pragmatic Studies PCORI Funding Announcement -- Cycle 3 2026
PCORI pre-announcement for high-impact patient-centered comparative clinical effectiveness research across broad health conditions, populations, and care settings.
- Funder
- Patient-Centered Outcomes Research Institute (PCORI)
- LOI deadline
- LOI deadline: Sep 8, 2026
- Award
- Up to USD 12 million direct costs
- Applicant
- Research Team
- Discipline
- Health & Biomedical Sciences
- Region
- United States
- Posted
- May 16, 2026
Call summary
Overview
PCORI intends to issue the Cycle 3 2026 Broad Pragmatic Studies funding announcement on 4 August 2026 for high-impact patient-centered comparative clinical effectiveness research.
Who can apply
- Research teams proposing patient-centered comparative clinical effectiveness studies should review the full PCORI announcement when it opens.
- Applicants are expected to involve patients and other healthcare partners in ways that make the research relevant and useful for healthcare decision making.
What it supports
- Large-scale pragmatic studies comparing existing interventions, treatments, care delivery strategies, or approaches in real-world settings.
- Special emphasis areas include mental health and substance use outcomes for pregnant and postpartum populations, cancer survivorship, diabetes, neuropathic pain, and pain in people living with intellectual and developmental disabilities or Alzheimer's disease and related dementias.
Funding and duration
Budgets may request up to USD 12 million in direct costs, with project periods up to five years.
LOI deadline
LOI deadline: Sep 8, 2026
How to apply
Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.
Call details
This is a pre-announcement. Use it for early planning and return to the official page when the full application package or portal opens.
PCORI intends to issue the Cycle 3 2026 Broad Pragmatic Studies funding announcement on 4 August 2026 for high-impact patient-centered comparative clinical effectiveness research.
Patient-Centered Outcomes Research Institute (PCORI) lists this opportunity for Research Team, Health & Biomedical Sciences, United States. Applicants should use the official call page to confirm final requirements before submitting.
Research teams proposing patient-centered comparative clinical effectiveness studies should review the full PCORI announcement when it opens.
Applicants are expected to involve patients and other healthcare partners in ways that make the research relevant and useful for healthcare decision making.
Large-scale pragmatic studies comparing existing interventions, treatments, care delivery strategies, or approaches in real-world settings.
Special emphasis areas include mental health and substance use outcomes for pregnant and postpartum populations, cancer survivorship, diabetes, neuropathic pain, and pain in people living with intellectual and developmental disabilities or Alzheimer's disease and related dementias.
Budgets may request up to USD 12 million in direct costs, with project periods up to five years.
LOI deadline: LOI deadline: Sep 8, 2026.
Confirm the exact deadline time, time zone, and submission route on the official call page.
Plan internal approvals, partner confirmations, budgets, letters, and portal submission before the final deadline.
Use the official PCORI announcement page. The PFA opens on 4 August 2026, the LOI deadline is 8 September 2026 at 5:00 pm ET, and invited applications are due 12 January 2027.
Before submitting, check required documents, eligible costs, attachments, page limits, institutional approvals, and whether the opportunity uses an expression of interest, full proposal, registration, or nomination stage.