Continuation of the Exceptional Longevity Data Management and Coordinating Center (EL DMCC) (U24 Clinical Trial Not Allowed)

Source-based overview

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to support the continued operation and expansion of the Exceptional Longevity Data Management and Coordinating Center (EL DMCC) through a single U24 cooperative agreement award. The NOFO will be open to all eligible applicants. Established in 2022, the EL DMCC serves as the central hub for NIA’s human longevity translational research portfolio, integrating data and activities across studies to maximize the value of deeply phenotyped cohorts and associated genomic and multi-omics datasets. The DMCC currently plays a critical role in enabling cross-cohort analyses, coordinating collaborative research, and advancing shared data resources. Core functions include data harmonization and integration; development and implementation of common data standards; provision of statistical, computational, and artificial intelligence and machine learning (AI/ML) infrastructure and tools; coordination of cross-project collaborations; and managing shared data systems, including data storage, access, and platform operations. The DMCC also develops and maintains the ELITE (Exceptional Longevity Translational Resources) Portal, which provides secure access to harmonized datasets, analytical tools, and cloud-based computational workspaces. The DMCC supports controlled access to EL data and use of these resources by the research community and maintains ongoing efforts to ensure the Portal is interoperable with the NIA Alzheimer’s Disease Knowledge Portal and other data resources of the National Institutes of Health, consistent with FAIR (Findable, Accessible, Interoperable, Reusable) data principles. Through the NOFO, the Coordinating Center will be expected to build on and expand these core functions by: Enhancing integration of increasingly large and diverse datasets across cohorts and species Expanding statistical, computational, and AI/ML capabilities and associated infrastructure Developing and refining methods and standards for multi-omics data harmonization and integrative analyses Coordinating and supporting collaborative research across NIA-funded projects Developing and disseminating translational resources, including target nomination and prioritization resources, curated target knowledgebases, and inventories of candidate therapeutic targets Advancing the ELITE Portal, including improvements in data organization, search, visualization, interoperability, and cloud-based analytical environments Strengthening community engagement through training, workshops, and collaborative activities Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The official record contains the controlling eligibility, budget, attachment and submission requirements for opportunity RFA-AG-27-004.

Eligibility

Eligible applicant types listed by the agency: For profit organizations other than small businesses; Private institutions of higher education; Public housing authorities/Indian housing authorities; Independent school districts; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); City or township governments; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; Native American tribal governments (Federally recognized). Applicants must also satisfy every programme-specific condition in the official notice.

Funding and benefits

Estimated programme funding: See official notice

Themes and supported activities

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to support the continued operation and expansion of the Exceptional Longevity Data Management and Coordinating Center (EL DMCC) through a single U24 cooperative agreement award. The NOFO will be open to all eligible applicants. Established in 2022, the EL DMCC serves as the central hub for NIA’s human longevity translational research portfolio, integrating data and activities across studies to maximize the value of deeply phenotyped cohorts and associated genomic and multi-omics datasets. The DMCC currently plays a critical role in enabling cross-cohort analyses, coordinating collaborative research, and advancing shared data resources. Core functions include data harmonization and integration; development and implementation of common data standards; provision of statistical, computational, and artificial intelligence and machine learning (AI/ML) infrastructure and tools; coordination of cross-project collaborations; and managing shared data systems, including data storage, access, and platform operations. The DMCC also develops and maintains the ELITE (Exceptional Longevity Translational Resources) Portal, which provides secure access to harmonized datasets, analytical tools, and cloud-based computational workspaces. The DMCC supports controlled access to EL data and use of these resources by the research community and maintains ongoing efforts to ensure the Portal is interoperable with the NIA Alzheimer’s Disease Knowledge Portal and other data resources of the National Institutes of Health, consistent with FAIR (Findable, Accessible, Interoperable, Reusable) data principles. Through the NOFO, the Coordinating Center will be expected to build on and expand these core functions by: Enhancing integration of increasingly large and diverse datasets across cohorts and species Expanding statistical, computational, and AI/ML capabilities and associated infrastructure Developing and refining methods and standards for multi-omics data harmonization and integrative analyses Coordinating and supporting collaborative research across NIA-funded projects Developing and disseminating translational resources, including target nomination and prioritization resources, curated target knowledgebases, and inventories of candidate therapeutic targets Advancing the ELITE Portal, including improvements in data organization, search, visualization, interoperability, and cloud-based analytical environments Strengthening community engagement through training, workshops, and collaborative activities Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

Opportunity number: RFA-AG-27-004

Deadline and timeline

Forecast notice: deadline to be announced: Forecast notice: deadline to be announced.

Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.

How to apply

Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.

Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.