Somatic Mosaicism across Human Tissues (SMaHT) Program: National Somatic Mosaicism Commons Data Analysis & Organizational Center (UM1 Clinical Trial Not Allowed)

Source-based overview

The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 through the National Somatic Mosaicism Commons Data Analysis & Organizational Center. The National Somatic Mosaicism Commons Data Analysis & Organizational Center combines data management and analysis with network governance, coordination, outreach, and training. The Center will develop tools and platforms that allow SMaHT Network members and the wider clinical and research communities to investigate and use these complex datasets. The center will be responsible for managing network data and providing access to data analysis tools developed in the program. This will include building the SMaHT data portal, Variant Catalog, variant browser, visualization tools, and analysis-ready releases. The center will also conduct outreach to clinical and research communities and provide training in SMaHT resources. The official record contains the controlling eligibility, budget, attachment and submission requirements for opportunity RFA-RM-28-016.

Eligibility

Eligible applicant types listed by the agency: City or township governments; Native American tribal governments (Federally recognized); State governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; Special district governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; Private institutions of higher education; Public and State controlled institutions of higher education; For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; County governments. Applicants must also satisfy every programme-specific condition in the official notice.

Funding and benefits

Estimated programme funding: See official notice

Themes and supported activities

The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 through the National Somatic Mosaicism Commons Data Analysis & Organizational Center. The National Somatic Mosaicism Commons Data Analysis & Organizational Center combines data management and analysis with network governance, coordination, outreach, and training. The Center will develop tools and platforms that allow SMaHT Network members and the wider clinical and research communities to investigate and use these complex datasets. The center will be responsible for managing network data and providing access to data analysis tools developed in the program. This will include building the SMaHT data portal, Variant Catalog, variant browser, visualization tools, and analysis-ready releases. The center will also conduct outreach to clinical and research communities and provide training in SMaHT resources.

Opportunity number: RFA-RM-28-016

Deadline and timeline

Forecast notice: deadline to be announced: Forecast notice: deadline to be announced.

Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.

How to apply

Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.

Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.