Grant opportunity

NIH Director's Transformative Research Award (R01 Clinical Trial Optional)

The NIH Director's Transformative Research Award supports individual scientists and research teams pursuing bold, groundbreaking, and unconventional research with the potential to transform science, create new scientific paradigms, establish new clinical approaches, or develop transformative technologies. The Transformative Research Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program .

Pre-announcementGrantHealth and Biomedical SciencesUnited StatesNational Institutes of HealthGrants.gov
Funder
National Institutes of Health
Forecast notice: deadline to be announced
Forecast notice: deadline to be announced
Award
See official notice
Applicant
County governments; Native American tribal governments (Federally recognized); Small businesses; Public housing authorities/Indian housing authorities; City or township governments; Native American tribal organizations (other than Federally recognized tribal governments); Special district governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; Private institutions of higher education; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; For profit organizations other than small businesses
Discipline
Health and Biomedical Sciences
Region
United States
Posted
Sep 7, 2026

Call summary

Overview

NIH Director's Transformative Research Award (R01 Clinical Trial Optional) is official opportunity RFA-RM-28-003, published by National Institutes of Health during the 31 August-7 September 2026 hunt window.

Who can apply

Eligible applicant types listed by the agency: County governments; Native American tribal governments (Federally recognized); Small businesses; Public housing authorities/Indian housing authorities; City or township governments; Native American tribal organizations (other than Federally recognized tribal governments); Special district governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; Private institutions of higher education; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; For profit organizations other than small businesses. Applicants must also satisfy every programme-specific condition in the official notice.

What it supports

  • The NIH Director's Transformative Research Award supports individual scientists and research teams pursuing bold, groundbreaking, and unconventional research with the potential to transform science, create new scientific paradigms, establish new clinical approaches, or develop transformative technologies. The Transformative Research Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program .
  • Opportunity number: RFA-RM-28-003

Funding and duration

  • Estimated programme funding: See official notice
  • Expected number of awards: 6

Forecast notice: deadline to be announced

Forecast notice: deadline to be announced

How to apply

Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.

Call details

Source-based overview

The NIH Director's Transformative Research Award supports individual scientists and research teams pursuing bold, groundbreaking, and unconventional research with the potential to transform science, create new scientific paradigms, establish new clinical approaches, or develop transformative technologies. The Transformative Research Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program . The official record contains the controlling eligibility, budget, attachment and submission requirements for opportunity RFA-RM-28-003.

Eligibility

Eligible applicant types listed by the agency: County governments; Native American tribal governments (Federally recognized); Small businesses; Public housing authorities/Indian housing authorities; City or township governments; Native American tribal organizations (other than Federally recognized tribal governments); Special district governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; Private institutions of higher education; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; For profit organizations other than small businesses. Applicants must also satisfy every programme-specific condition in the official notice.

Funding and benefits

Estimated programme funding: See official notice

Expected number of awards: 6

Themes and supported activities

The NIH Director's Transformative Research Award supports individual scientists and research teams pursuing bold, groundbreaking, and unconventional research with the potential to transform science, create new scientific paradigms, establish new clinical approaches, or develop transformative technologies. The Transformative Research Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program .

Opportunity number: RFA-RM-28-003

Deadline and timeline

Forecast notice: deadline to be announced: Forecast notice: deadline to be announced.

Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.

How to apply

Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.

Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.