Grant opportunity

NIH Director's Pioneer Award (DP1 Clinical Trial Optional)

The NIH Director's Pioneer Award supports exceptionally creative scientists pursuing bold, innovative research with the potential to transform important areas of science relevant to the NIH mission. Proposed projects must explore new scientific directions that differ substantially from the investigator's current research and from existing work in the field. Applications are welcome across all areas relevant to NIH. The Pioneer Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program .

Pre-announcementGrantHealth and Biomedical SciencesUnited StatesNational Institutes of HealthGrants.gov
Funder
National Institutes of Health
Forecast notice: deadline to be announced
Forecast notice: deadline to be announced
Award
USD 700,000
Applicant
Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; For profit organizations other than small businesses; Special district governments; Native American tribal governments (Federally recognized); Public housing authorities/Indian housing authorities; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; City or township governments; Private institutions of higher education
Discipline
Health and Biomedical Sciences
Region
United States
Posted
Sep 7, 2026

Call summary

Overview

NIH Director's Pioneer Award (DP1 Clinical Trial Optional) is official opportunity RFA-RM-28-001, published by National Institutes of Health during the 31 August-7 September 2026 hunt window.

Who can apply

Eligible applicant types listed by the agency: Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; For profit organizations other than small businesses; Special district governments; Native American tribal governments (Federally recognized); Public housing authorities/Indian housing authorities; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; City or township governments; Private institutions of higher education. Applicants must also satisfy every programme-specific condition in the official notice.

What it supports

  • The NIH Director's Pioneer Award supports exceptionally creative scientists pursuing bold, innovative research with the potential to transform important areas of science relevant to the NIH mission. Proposed projects must explore new scientific directions that differ substantially from the investigator's current research and from existing work in the field. Applications are welcome across all areas relevant to NIH. The Pioneer Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program .
  • Opportunity number: RFA-RM-28-001

Funding and duration

  • Award ceiling: USD 700,000
  • Expected number of awards: 7

Forecast notice: deadline to be announced

Forecast notice: deadline to be announced

How to apply

Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.

Call details

Source-based overview

The NIH Director's Pioneer Award supports exceptionally creative scientists pursuing bold, innovative research with the potential to transform important areas of science relevant to the NIH mission. Proposed projects must explore new scientific directions that differ substantially from the investigator's current research and from existing work in the field. Applications are welcome across all areas relevant to NIH. The Pioneer Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program . The official record contains the controlling eligibility, budget, attachment and submission requirements for opportunity RFA-RM-28-001.

Eligibility

Eligible applicant types listed by the agency: Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; For profit organizations other than small businesses; Special district governments; Native American tribal governments (Federally recognized); Public housing authorities/Indian housing authorities; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; City or township governments; Private institutions of higher education. Applicants must also satisfy every programme-specific condition in the official notice.

Funding and benefits

Award ceiling: USD 700,000

Expected number of awards: 7

Themes and supported activities

The NIH Director's Pioneer Award supports exceptionally creative scientists pursuing bold, innovative research with the potential to transform important areas of science relevant to the NIH mission. Proposed projects must explore new scientific directions that differ substantially from the investigator's current research and from existing work in the field. Applications are welcome across all areas relevant to NIH. The Pioneer Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program .

Opportunity number: RFA-RM-28-001

Deadline and timeline

Forecast notice: deadline to be announced: Forecast notice: deadline to be announced.

Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.

How to apply

Open the official Grants.gov record, review the full notice and attachments, and use the application package or agency route stated there.

Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.