Grant opportunity
Broad Pragmatic Studies PCORI Funding Announcement: Cycle 2 2026
PCORI funding for large pragmatic comparative clinical effectiveness studies that address critical decisions faced by patients, caregivers, clinicians, and health systems.
- Funder
- Patient-Centered Outcomes Research Institute (PCORI)
- Deadline
- Sep 1, 2026
- Award
- Up to USD 12 million direct costs depending on category
- Applicant
- Research Team
- Discipline
- Public Health
- Region
- United States
- Posted
- May 13, 2026
Call summary
Overview
The Broad Pragmatic Studies PFA supports patient-centered comparative clinical effectiveness research designed to generate evidence for real-world decisions.
Who can apply
- The LOI deadline for Cycle 2 has passed; the September application deadline applies to invited applicants.
- Applicants should follow PCORI's eligibility, stakeholder engagement, and methodology standards.
What it supports
- Pragmatic clinical studies.
- Patient-centered comparative effectiveness research.
- Projects addressing major health decisions and evidence gaps.
Funding and duration
PCORI lists up to USD 120 million available across categories, with category budgets up to USD 12 million in direct costs.
Application deadline
Sep 1, 2026
How to apply
Invited applicants submit the full application through PCORI by 1 September 2026 at 5:00 p.m. Eastern Time.
Call details
The Broad Pragmatic Studies PFA supports patient-centered comparative clinical effectiveness research designed to generate evidence for real-world decisions.
Patient-Centered Outcomes Research Institute (PCORI) lists this opportunity for Research Team, Public Health, United States. Applicants should use the official call page to confirm final requirements before submitting.
The LOI deadline for Cycle 2 has passed; the September application deadline applies to invited applicants.
Applicants should follow PCORI's eligibility, stakeholder engagement, and methodology standards.
Pragmatic clinical studies.
Patient-centered comparative effectiveness research.
Projects addressing major health decisions and evidence gaps.
PCORI lists up to USD 120 million available across categories, with category budgets up to USD 12 million in direct costs.
Application deadline: Sep 1, 2026.
Confirm the exact deadline time, time zone, and submission route on the official call page.
Plan internal approvals, partner confirmations, budgets, letters, and portal submission before the final deadline.
Invited applicants submit the full application through PCORI by 1 September 2026 at 5:00 p.m. Eastern Time.
Before submitting, check required documents, eligible costs, attachments, page limits, institutional approvals, and whether the opportunity uses an expression of interest, full proposal, registration, or nomination stage.