NIH Director's Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

Source-based overview

National Institutes of Health has posted NIH Director's Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional), a health and biomedical sciences funding opportunity listed on Grants.gov under opportunity number RFA-RM-27-003. The call is relevant to Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; County governments; Independent school districts; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Special district governments; Public housing authorities/Indian housing authorities; Native American tribal governments (Federally recognized); Private institutions of higher education; City or township governments and should be reviewed on the official listing for final eligibility, forms, attachments and submission timing.

Eligibility

Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; County governments; Independent school districts; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; Native American tribal organizations (other than Federally recognized tribal governments); Small businesses; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Special district governments; Public housing authorities/Indian housing authorities; Native American tribal governments (Federally recognized); Private institutions of higher education; City or township governments. Applicants should confirm all additional eligibility limits, cost-sharing rules, institutional requirements and application package instructions on the official Grants.gov page.

Funding and benefits

Up to USD 8,000,000

Themes and supported activities

Opportunity number: RFA-RM-27-003

Funding category: Health

Funding instrument: Grant

Deadline and timeline

Application deadline: Application deadline: Sep 3, 2026.

Applicants should confirm the exact deadline time, time zone, required documents, portal steps and any institutional approvals on the official call page before submitting.

How to apply

Open the official Grants.gov listing, review the full notice of funding opportunity and application package, then submit through the Grants.gov route specified by the agency.

Before applying, check eligibility rules, budgets, attachments, page limits, partner requirements, cost-share conditions and whether the opportunity uses an expression of interest, full proposal, registration or nomination stage.